Patients with Ehlers-Danlos Syndrome looking to boost their sleep quality will like what Puffy Lux Hybrid offers. Its memory foam helps alleviate shoulder pain, while the Counter-Adapt Coils provide gentle pushback for proper support and spinal alignment.

Puffy Lux Hybrid is a medium-firm mattress with a slightly above-average firmness scale of about 6.0/10. The firmness level makes it ideal for EDS sufferers with connective tissue complications, resulting in fragile skin. Its ultra-firm plush feel offers light and average-weight EDS patients tremendous pressure relief for a more restful sleep. 

The firmness scale, combined with the Counter-Adapt Steel Coils, gives the mattress proper edge support sufficient for EDS patients. The mattress also has a dense, firm foam that forms double reinforcement for the edge support. So, if you have Ehlers-Danlos Syndrome, there's no need to worry about joint pain or developing loose joints when climbing the bed.

Unlike a typical memory foam mattress, these hybrid mattresses are excellently responsive as it allows easy movement on the surface. Also, as you shift sleeping positions, the surface reacts quickly, regaining its normal form instantly—thanks to the pushback offered by its pocketed steel coils. 

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Amerisleep as3 is a versatile all-foam mattress with incredible cooling capabilities, thanks to its open-celled Bio-Pur Foam and Refresh Cooling Cover. As its Bio-Pur Foam excellently relieves pressure, the HiVE transition layer offers zoned support, making it an excellent pick for EDS patients.

The AS3 is the best memory foam mattress which conforms but has a quick response that is ideal for pressure point relief. Unlike some memory foam mattresses, the AS3 is unique since it doesn't make you feel stuck in the material. As a supportive mattress, the AS3 offers an incredibly harmonious blend of weightlessness and proper support for relieving pressure points.

Like other foam mattresses in the Amerisleep line, AS3 also offers a similar contouring hug-like memory foam feel. Amerisleep uses Bio-Pur Foam in its construction, giving it the industry standard firmness scale of 6.5/10. Because firmness level is a subjective metric, heavyweight sleepers may consider this AS3 model a soft mattress than average and lightweights.

The mattress offers decent edge support. And because it's a medium-firm mattress, EDS sufferers with hypermobile joints don't have to worry about further joint pain when getting on this bed. AS3's memory foam reasonably responds quickly, making movement on its surfaces relatively easy.

GhostBed Venus Williams Legend is fitted with cutting-edge technology for outstanding cooling, pressure point relief, and ease of movement.

The mattress features Exclusive Venus FIT Layer in its design which offers quick muscle pain relief for a restorative good night's sleep. Moreover, the venus fit layer makes this the best mattress for EDS patients experiencing problems with connective tissues. The Venus FIT technology allows for efficient blood flow. And with its springy coils, it provides the internal human body organs with spectacular internal support and cohesion.

Venus Williams Legend is made with one of the most breathable materials making it a high quality mattress for hot summers. Notably, REPREVE® and naturally cooling fibers make Venus Williams Legend breathable and soft. Like all-foam medium firm mattresses, Venus Williams Legend's memory foam contours with heavy body curves and offers the shoulders and hips pain relief which prevents bed sores.

Like some innerspring mattresses, Venus Williams Legend bears responsiveness similar to latex mattresses. This is courtesy of the 2" Ghost Bounce Layer. As it supports one's weight, it also absorbs all the movements and motion from a sleeping partner, thanks to its incredible motion isolation.

SleepOvation is a one-of-a-kind mattress with unique technology designed to offer a world-class sleep experience. SleepOvation has 700 tiny mattresses that offer tremendous relief on targeted pressure points—which makes it a good mattress for people with Ehlers-Danlos Syndrome.

Since it's a 700-in-one mattress, the air channels between the tiny mattresses boost airflow throughout the mattress's surface. Moreover, its cover also helps shield you against night sweats by wicking away moisture and humidity.

Generally, a firmer mattress surface may interfere with the normal texture of Ehlers-Danlos Syndrome patients' skin. But since SleepOvation offers targeted relief on pressure points, its surface provides a soft, plush feel for people with itchy skin disorders.

Generally, this is a medium-firm mattress. Notably, its excellent edge support and solid responsiveness make it ideal for EDS sufferers. Additionally, sleepers who experience sleep problems due to further joint pain after climbing the bed will like its exceptionally relieving comfort.

Made with high-quality, luxurious eco-friendly materials, PlushBed guarantees an eco-cautious individuals sleep comfort like no other. PlushBed Bliss is one of the few spring mattresses in the mattress industry made of entirely natural materials. 

Like most latex mattresses, PlushBed Bliss offers exceptional breathability and cooling capabilities, helping prevent night sweats. That, with its natural materials, lets you breathe comfortably without worrying about any VOCs or sweat and other gunk that may build up and release an awful smell.  

Notably, PlushBed Bliss comes in two firmness options; firm and medium firm models. It also has quite an impressive edge support achieved through the coil count reinforcing its perimeter. Surprisingly, the mattress's edge can support one's weight excellently with minimal compression. Overall, this makes it easy for an Ehlers-Danlos Syndrome patient to get into bed without worrying about further joint pain.

If you want to upgrade your bedroom with a new mattress for Ehlers-Danlos Syndrome patient, you should consider Nolah Original. From its excellent edge support to medium firmness and top-notch cooling, Nolah is comfortable for an individual with such a condition.

Nolah Original is a medium-firm mattress with a firmness scale of 6.0/10, ideal for all sleep positions. With this firmness level, it offers an average-weight sleeper excellent cushioning for relief on your pressure points.

Its transitional and polyfoam layers, in conjunction with the medium firmness, make it primarily ideal for average-weight side sleepers. Additionally, it offers back and stomach sleepers proper support and comfort for pain relief. 

With its Supportive High-Resilience transition foam layer, this mattress excels quite well in responsiveness. Moreover, it helps prevent excessive sinkage while keeping the spine aligned properly. And with top-notch comfort and support balance, it helps relieves Ehlers Danlos Syndrome patients of chronic fatigue. Overall, people with loose joints, itchy skin disorders, and chronic pain in the back, hip, and upper body stand to gain significantly from Nolah Original 10". Click here for more information about the best mattress for pain relief after hip surgery.

With Layla Mattress, an EDS patient can easily customize their sleep comfort depending on their preference. For instance, patients who like the cradling feel of a soft mattress should opt for the medium firm level.

Layla is great at dissipating heat and maintaining a neutral temperature. Though typical memory foam tends to trap heat, Layla's medium firm level counteracts this through copper gel infusion—trapping and dissipating body heat.

The firmer side bears the industry standard firmness scale of 6.5/10, while the medium-firm level is 4.0/10. Also, unlike most all-foam mattresses, such as TempurPedic and Casper mattresses, which have foundations at the first layer, Layla's sits at the center. The position of the foundation and firmness level of each side makes movement on either side relatively easy.

The Layla Mattress has slightly above-average edge support on both sides. Notably, this allows an EDS patient to climb easily onto and off the bed without dislocating their joints or compromising their fragile skin.