GhostBed 3D Matrix is a smart bed with all the bells and whistles to help boost an Ankylosing Spondylitis patient's sleep quality. Among 3D's selling points is the cooling technology stemming from its gel memory foam, cooling cover, and 3D matrix polymer layer.

The cover is woven with cool-to-the-touch Ghost Ice Fabric, offering instant cooling relief to hot sleepers. For boosted cooling, its second layer is fitted with 3D Matrix Polymer that absorbs and distributes body heat across the mattress surface.

The 3D Matrix has adjustable firmness, allowing you to optimize its firmness automatically for excellent relief of pressure. Moreover, it can adjust itself to conform to your sleeping positions, promoting proper spinal alignment and ensuring you get optimal support. Though ideal for back sleepers with back pain, it's an excellent option for side sleepers with chronic pain in the hips and shoulders. This is thanks to its auto pressure relief setting, which also makes this bed a viable pick for sleepers on the hunt for the best mattress for hip replacement patients.

Like most adjustable beds, the 3D Matrix is compatible with standard adjustable bed frames, foundations, slats, and box springs. Overall the smart bed's futuristic features, in conjunction with an adjustable bedframe, guarantee an AS sufferer an exceptional sleep experience.

In Amerisleep's line, the As3 Memory Foam Mattress is the best-selling model. Plus, it's considered universally comfortable and offers excellent value for your money.

Considered the best cooling mattress in Amerisleep's catalog by most sleepers, it has an excellently designed cool-to-the-touch polyester cover and a 2-inch transition layer. The cover features spandex and Celliant in its construction. While the Celliant component offers cooling relief—by transforming body heat into infrared—the spandex is stretchy to adjust to the body's shape.

The AS3's transition layer is a bit stiffer and more responsive than the comfort layer. Within this layer are the HiVE technology and the Bio-Pur foam, which allows free air travel, shielding you from night sweats. More importantly, the HiVE Layer is excellently zoned to support different body parts. The zoning also promotes excellent spinal alignment and relieves overall body pain especially back pain.

Like most memory foam mattresses, As3 bears a firmness scale of 6.5/10, ideal for an average-weight sleeper with Ankylosing Spondylitis. With this firmness level, it's considered a medium firm mattress. Its plush soft top layer allows enough sinkage to cradle the body while providing balanced cushioning support—thanks to its support and transition foam layer.

SleepOvation features cutting-edge technology best for a sleeper seeking a properly cooling pressure reliving, medium firm option.

At its comfort layer, this hybrid mattress features 700 tiny mattresses which relieve pressure on painful target pressure points. Regardless of your preferred sleeping position (except stomach sleeping if you have Ankylosing Spondylitis), the mattress provides individualized comfort and support while excellently adapting to your body shape.

Covering the entire mattress is the cool-to-the-touch, removable, machine-washable cover. The cover is thin, offering a hot sleeper with amazing cooling relief. Also, the tiny mattresses feature "Cushion Pocket" technology to boost the overall breathability of the entire mattress.

SleepOvation is a good option for sleepers seeking a firmer mattress. With a mattress firmness of 6.5/10, SleepOvation's construction is formulated to promote healthy spinal alignment, back pain, and joint pain relief. Like innerspring mattresses, SleepOvation offers a great comfort and support balance ideal for a sleeper with Ankylosing Spondylitis.

MOLECULE Hybrid is an exceptionally comfortable mattress with top-notch breathability and pressure-relieving capabilities. These and other features are ideal for an Ankylosing Spondylitis patient and athletes with an active lifestyle.

MOLECULE hybrid mattresses tend to sag at the edge during occasional sitting or just lying. However, this MOLECULE mattress' comfort layer and the sturdy support core add some solid reinforcement to its edges. Overall, its strong edge support is sufficient enough to prevent you from rolling off the bed or sliding when sleeping or just sitting.

MOLECULE's firmness level is on the medium firm side, with a scale of 6.0/10. So, as a plush soft mattress, it is excellently pressure-relieving, leaving your body pain free when you wake up rejuvenated. Additionally, the mattress' coil system and the support layers make it firmer to provide maximum support around the lumbar region.

Due to its exceptional motion isolation, you don't have to worry about sleep disturbances due to tosses and turns from a co-sleeper or a sleep partner. This is thanks to its top slow-moving memory foam layer in conjunction with the coil system, ensuring minimal motion transfer.

Most all-foam mattresses are known to trap and retain heat, which may cause some sleep discomfort. However, such is not the case with Nolah Signature since its memory foam layers are designed with temperature-neutral viscoelastic materials. It also has heat-dissipating microscopic air pockets, which help improve overall heat dissipation.

Firmness is a subjective feel factor, and unlike most memory foam mattresses, Nolah Signature has two firmness levels. On its soft side, most sleepers consider it a medium soft option, while its firmer side makes it a medium firm mattress. Since body weight, to some extent, determines comfort preference, the softer side is ideal for lightweight sleepers, while the firmer side is fit for heavyweight sleepers.

Spinal alignment and pressure relief are two metrics Nolah Signature excels at. Both sides of the mattress allow sufficient sinkage for maximum pressure relief, especially for those who sleep on their side. The relief primarily stems from its thick AirFoam layer cushioning the hips and the shoulders. To maintain a healthy spinal alignment on this mattress, common sleep positions to adapt are back and side sleeping.

Puffy is a carefully tested mattress, and the customer reviews suggest it's among the top-rated mattresses better suited for side sleepers.

Unlike traditional memory foam, the puffy mattress's Climate Comfort™ Foam expands and contracts to maintain a neutral temperature. For instance, if the environmental temperature is cold, it contracts and expands when it's hot. Such Foam variability makes Puffy the right mattress for Ankylosing Spondylitis patients seeking Maximum pressure relief.

Puffy is a suitable option for sleepers looking for an extra firm mattress. The mattress bears a firmness scale of 7.0/10, which is firmer than the industry standard of 6.5/10. With this level of mattress firmness, it delivers an unparalleled conforming and cushioning ability for pressure relief for average and heavyweight sleepers.

The Puffy Mattress bears an excellent responsive level, almost similar to that of latex mattresses. Its responsiveness produces bounciness keeping you from sinking too deep into the material. Since there's efficient ease of movement on the surface, you shouldn't have difficulties switching to a different sleeping position.

Though ideal for athletes, Zoma Hybrid is a spectacular option for Ankylosing Spondylitis sleepers seeking a restorative, cooler sleep.

The mattress is designed with a breathable mesh fabric cover consisting of a 3% spandex and 97% polyester material blend. The cover, combined with a perforated gel foam layer and pocketed coils, enhances the mattress's overall breathability.

Compared to average hybrid mattresses, Zoma Hybrid is firmer, with a scale of 6.5/10. Its soft top foam layer is fast responding, excellently pressure relieving, and simultaneously responsive.

The mattress is zoned to feel softer or firmer, depending on the sleeping position. Zoma Hybrid feels relatively firmer for a back sleeper but with a balanced comfort ideal for an AS patient. Its 2-inch polyfoam layer and 7-inch pocketed coil support core limit excessive sinkage into the mattress, boosting ease of movement on the sleep surface.